High content imaging assays can capture rich phenotypic response data for large sets of compound treatments, aiding in the characterization and discovery of novel drugs. However, extracting representative features from high content images that can capture subtle nuances in phenotypes remains challenging. The lack of high-quality labels makes it difficult to achieve satisfactory results with supervised deep learning. Self-Supervised learning methods, which learn from automatically generated labels has shown great success on natural images, offer an attractive alternative also to microscopy images. However, we find that self-supervised learning techniques underperform on high content imaging assays. One challenge is the undesirable domain shifts present in the data known as batch effects, which may be caused by biological noise or uncontrolled experimental conditions. To this end, we introduce Cross-Domain Consistency Learning (CDCL), a novel approach that is able to learn in the presence of batch effects. CDCL enforces the learning of biological similarities while disregarding undesirable batch-specific signals, which leads to more useful and versatile representations. These features are organised according to their morphological changes and are more useful for downstream tasks - such as distinguishing treatments and mode of action.

视觉变压器已经证明了在各种视觉任务中胜过CNN的潜力。但是这些模型的计算和内存要求禁止在许多应用中使用它们，尤其是依赖高分辨率图像的应用程序，例如医学图像分类。更有效地训练VIT的努力过于复杂，需要进行建筑变化或复杂的培训方案。在这项工作中，我们表明可以通过随机删除输入图像贴片来有效地以高分辨率进行标准VIT模型。这种简单的方法（PatchDropout）在标准的自然图像数据集（例如ImageNet）中将拖鞋和内存减少至少50％，而这些节省仅随图像尺寸而增加。在高分辨率医疗数据集CSAW上，我们使用PatchDropout可节省5倍的计算和内存，并提高性能。对于具有固定计算或内存预算的从业人员，PatchDropout可以选择图像分辨率，超参数或模型大小以使其从模型中获得最大的性能。

转移学习是一种标准技术，可以将知识从一个领域转移到另一个领域。对于医学成像中的应用，尽管域之间的任务和图像特征差异，但从Imagenet转移已成为事实上的方法。但是，尚不清楚哪些因素决定了哪些因素以及在何种程度上转移学习到医疗领域是有用的。最近，人们对源域重复使用的特征的长期假设最近受到质疑。通过在几个医学图像基准数据集上进行的一系列实验，我们探讨了传输学习，数据大小，模型的容量和电感偏置以及源域和目标域之间的距离之间的关系。我们的发现表明，在大多数情况下，转移学习是有益的，我们表征了重要的角色重复使用在其成功方面。

Given a large graph with few node labels, how can we (a) identify the mixed network-effect of the graph and (b) predict the unknown labels accurately and efficiently? This work proposes Network Effect Analysis (NEA) and UltraProp, which are based on two insights: (a) the network-effect (NE) insight: a graph can exhibit not only one of homophily and heterophily, but also both or none in a label-wise manner, and (b) the neighbor-differentiation (ND) insight: neighbors have different degrees of influence on the target node based on the strength of connections. NEA provides a statistical test to check whether a graph exhibits network-effect or not, and surprisingly discovers the absence of NE in many real-world graphs known to have heterophily. UltraProp solves the node classification problem with notable advantages: (a) Accurate, thanks to the network-effect (NE) and neighbor-differentiation (ND) insights; (b) Explainable, precisely estimating the compatibility matrix; (c) Scalable, being linear with the input size and handling graphs with millions of nodes; and (d) Principled, with closed-form formula and theoretical guarantee. Applied on eight real-world graph datasets, UltraProp outperforms top competitors in terms of accuracy and run time, requiring only stock CPU servers. On a large real-world graph with 1.6M nodes and 22.3M edges, UltraProp achieves more than 9 times speedup (12 minutes vs. 2 hours) compared to most competitors.

While risk-neutral reinforcement learning has shown experimental success in a number of applications, it is well-known to be non-robust with respect to noise and perturbations in the parameters of the system. For this reason, risk-sensitive reinforcement learning algorithms have been studied to introduce robustness and sample efficiency, and lead to better real-life performance. In this work, we introduce new model-free risk-sensitive reinforcement learning algorithms as variations of widely-used Policy Gradient algorithms with similar implementation properties. In particular, we study the effect of exponential criteria on the risk-sensitivity of the policy of a reinforcement learning agent, and develop variants of the Monte Carlo Policy Gradient algorithm and the online (temporal-difference) Actor-Critic algorithm. Analytical results showcase that the use of exponential criteria generalize commonly used ad-hoc regularization approaches. The implementation, performance, and robustness properties of the proposed methods are evaluated in simulated experiments.

Hierarchical learning algorithms that gradually approximate a solution to a data-driven optimization problem are essential to decision-making systems, especially under limitations on time and computational resources. In this study, we introduce a general-purpose hierarchical learning architecture that is based on the progressive partitioning of a possibly multi-resolution data space. The optimal partition is gradually approximated by solving a sequence of optimization sub-problems that yield a sequence of partitions with increasing number of subsets. We show that the solution of each optimization problem can be estimated online using gradient-free stochastic approximation updates. As a consequence, a function approximation problem can be defined within each subset of the partition and solved using the theory of two-timescale stochastic approximation algorithms. This simulates an annealing process and defines a robust and interpretable heuristic method to gradually increase the complexity of the learning architecture in a task-agnostic manner, giving emphasis to regions of the data space that are considered more important according to a predefined criterion. Finally, by imposing a tree structure in the progression of the partitions, we provide a means to incorporate potential multi-resolution structure of the data space into this approach, significantly reducing its complexity, while introducing hierarchical feature extraction properties similar to certain classes of deep learning architectures. Asymptotic convergence analysis and experimental results are provided for clustering, classification, and regression problems.

Being able to forecast the popularity of new garment designs is very important in an industry as fast paced as fashion, both in terms of profitability and reducing the problem of unsold inventory. Here, we attempt to address this task in order to provide informative forecasts to fashion designers within a virtual reality designer application that will allow them to fine tune their creations based on current consumer preferences within an interactive and immersive environment. To achieve this we have to deal with the following central challenges: (1) the proposed method should not hinder the creative process and thus it has to rely only on the garment's visual characteristics, (2) the new garment lacks historical data from which to extrapolate their future popularity and (3) fashion trends in general are highly dynamical. To this end, we develop a computer vision pipeline fine tuned on fashion imagery in order to extract relevant visual features along with the category and attributes of the garment. We propose a hierarchical label sharing (HLS) pipeline for automatically capturing hierarchical relations among fashion categories and attributes. Moreover, we propose MuQAR, a Multimodal Quasi-AutoRegressive neural network that forecasts the popularity of new garments by combining their visual features and categorical features while an autoregressive neural network is modelling the popularity time series of the garment's category and attributes. Both the proposed HLS and MuQAR prove capable of surpassing the current state-of-the-art in key benchmark datasets, DeepFashion for image classification and VISUELLE for new garment sales forecasting.

As aerial robots are tasked to navigate environments of increased complexity, embedding collision tolerance in their design becomes important. In this survey we review the current state-of-the-art within the niche field of collision-tolerant micro aerial vehicles and present different design approaches identified in the literature, as well as methods that have focused on autonomy functionalities that exploit collision resilience. Subsequently, we discuss the relevance to biological systems and provide our view on key directions of future fruitful research.

The Forster transform is a method of regularizing a dataset by placing it in {\em radial isotropic position} while maintaining some of its essential properties. Forster transforms have played a key role in a diverse range of settings spanning computer science and functional analysis. Prior work had given {\em weakly} polynomial time algorithms for computing Forster transforms, when they exist. Our main result is the first {\em strongly polynomial time} algorithm to compute an approximate Forster transform of a given dataset or certify that no such transformation exists. By leveraging our strongly polynomial Forster algorithm, we obtain the first strongly polynomial time algorithm for {\em distribution-free} PAC learning of halfspaces. This learning result is surprising because {\em proper} PAC learning of halfspaces is {\em equivalent} to linear programming. Our learning approach extends to give a strongly polynomial halfspace learner in the presence of random classification noise and, more generally, Massart noise.

3D gaze estimation is most often tackled as learning a direct mapping between input images and the gaze vector or its spherical coordinates. Recently, it has been shown that pose estimation of the face, body and hands benefits from revising the learning target from few pose parameters to dense 3D coordinates. In this work, we leverage this observation and propose to tackle 3D gaze estimation as regression of 3D eye meshes. We overcome the absence of compatible ground truth by fitting a rigid 3D eyeball template on existing gaze datasets and propose to improve generalization by making use of widely available in-the-wild face images. To this end, we propose an automatic pipeline to retrieve robust gaze pseudo-labels from arbitrary face images and design a multi-view supervision framework to balance their effect during training. In our experiments, our method achieves improvement of 30% compared to state-of-the-art in cross-dataset gaze estimation, when no ground truth data are available for training, and 7% when they are. We make our project publicly available at https://github.com/Vagver/dense3Deyes.